For generations, the “foolishness” has suddenly struck middle-age members of an extended family in Colombia’s Antioquia region. It starts with mild forgetfulness but soon reduces its victims to infantile incapacitation.
People here have long attributed La Bobera to a host of superstitions: a mythic priest’s revenge or touching a mysterious tree. Scientists now know it is a genetic mutation, concentrated by the intermarriage that’s not unusual in this rather isolated area. The malady is a type of early-onset Alzheimer’s Disease.
It’s called the “Paisa Mutation” because this clan of 5,000 are called Paisas. They are descended primarily from a group of 16th Century Spanish immigrants. By studying this mutation, researchers hope to learn more about other forms of Alzheimer’s and its treatment. Pam Belluck shares the dramatic details on the disease and its discovery, along with hopes for treatment, in a recent story in The New York Times.
This isn’t the first time genetic discovery has taken place in the Paisa population. In fact, researchers studying this unique group of people have learned much about ADHD from them, too. For example, a genetic link between ADHD and conduct disorder/oppositional defiance disorder was discovered by studying selected Paisa families (multi-generational). Read the rest of this entry »
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